Symptoms observed in some patients with abetalipoproteinemia are indistinguishable from those of patients with homozygous hypobetalipoproteinemia (HBLP), a codominant genetic disorder characterized by decreased or absent plasma levels of apolipoprotein (apo) B, due to mutations in the apo B gene (chromosome 2p24) [32,33] (for review see [34]). This evidence concerns the gene APOB and hereditary disease.