NFKB1 and diabetes mellitus: The observation that the GLUT4:NFκB ratio declined with weight gain, independent of exposure history (Figure 1A) and with higher serum dioxin residues among comparison individuals (Figure 2C), particularly obese individuals with family history of diabetes (Figure 3C), suggests that dioxin works synergistically with known diabetes risk factors to alter glucose metabolism in a way that resembles the inflammation mechanism of weight gain.