NFKB1 and obesity due to melanocortin 4 receptor deficiency: It is also important to point out that, despite the above “reversal” phenomenon in the relationship between GLUT4:NFκB ratio and dioxin, all non-diabetic individuals with significant dioxin residues, including those with residue levels > 5.3 ppt, still show the clear sign of the obesity-related risk of diabetes, judging by the results of experiments shown in Figure 4C.