NFKB1 and obesity due to melanocortin 4 receptor deficiency: However, our finding regarding this effect of GLUT4:NFκB was somewhat surprising in view of the lack of correlation of GLUT4:NFκB with weight gain among diabetic subjects (Figure 1B); this finding suggests that once the study subjects develop diabetes, the GLUT4:NFκB ratio does not work well as a biomarker for obesity.