Inhaled drugs, such as salmeterol, tiotropium, theophylline, or glucocorticoids (e.g., budesonide, prednisone), with an established role in chronic obstructive pulmonary disease or asthma treatment (Global Initiative for Asthma 2005; Global Initiative for Chronic Obstructive Lung Disease 2005) are substrates for CYP3A isoforms (Jonsson et al. 1995; Zevin and Benowitz 1999). This evidence concerns the gene CYP3A4 and chronic obstructive pulmonary disease.