In our studies, we also demonstrated that PTTG not only regulates the expression of MMP-2 in vitro but it does regulate MMP-2 expression and function in vivo (Fig. 7), however, it remains unclear if blocking of MMP-2 activity in vivo will inhibit angiogenesis and tumor development as result of overexpression of PTTG in tumors. The gene discussed is PTTG1; the disease is neoplasm.