Prevalences of P. falciparum (X2 = 24.45, p < 0.001), clinical malaria (X2 = 14.84, p < 0.001), and anaemia (X2 = 29.85, p < 0.001) were higher, and mean Hb levels lower (p < 0.001), in Moshie Zongo compared to Manhyia. The gene discussed is GSTM1; the disease is anemia.