Michaloglou et al., [99] have reported that in cultures of human melanocytes and naevi, the benign precursors of malignant melanoma, an oncogenic allele BRAF, a protein kinase downstream of Ras, derived from human melanomas can induce sustained cell cycle arrest and senescence in fibroblasts and melanocytes, accompanied by the expression of p16INK4a and the common senescence marker, SA-β-gal. This evidence concerns the gene BRAF and melanoma.