STXBP1 and Alzheimer disease: Besides the fact that there seemed to be more down- than up- regulated genes in the AD brains where neurodegeneration was already evident [2,3]., we cannot offer an definite explanation why some genes, such as, Syntaxin binding protein 1 and kinesin 2 found up-regulated by STAR procedure, consistent with the results obtained by others [3,32,33], yet not confirmed by qRT-PCR.