The crosstalk interaction between tumour cells and adjacent stromal cells participates in tumour immune escape, spreading and angiogenesis, which is conducted by a number of soluble and membrane molecules, including soluble Fas, Fas ligand, soluble MMPs, soluble VEGF and EMMPRIN (Zheng et al, 2003; Tang et al, 2005). This evidence concerns the gene VEGFA and neoplasm.