Furthermore, EMMPRIN transfection of tumour cells or treating tumour cells with the recombinant protein increased the expression of MMPs, especially MMP-2 (Sun and Hemler, 2001), as also evidenced by the positive correlation of EMMPRIN expression with MMP-2 and MMP-9 expression in our cases of gastric carcinoma. This evidence concerns the gene MMP2 and neoplasm.