Preincubation of microvascular endothelial cells with the superoxide anion producing xanthine–xanthine oxidase complex significantly increased adhesion of the human colon carcinoma cells HT29 (167% vs control, P<0.01), Caco2 (164% vs control, P<0.01) and of the pancreas carcinoma cells PanC1 (180% vs control, P<0.01). This evidence concerns the gene XDH and familial pancreatic carcinoma.