In a previous study, we have shown that although LYVE-1 expression on LVs located at the tumour periphery was strong, no or weak immunoreactivity was found in intratumoral LVs and that podoplanin is the best marker to visualise LVs in and around primary breast tumours (Van der Auwera et al, 2005). The gene discussed is PDPN; the disease is breast neoplasm.