Thus, loss of PTEN function owing to mutations, haploinsufficiency from LOH and hypermethylation, which are known to be present in 30–40% of gastric cancers (Kang et al, 2002; Oki et al, 2005), can lead to the constitutive activation of PI3K/Akt pathway. The gene discussed is AKT1; the disease is gastric cancer.