Alimandi et al (1995)Previously reported the increased recruitment of PI3K by the formation of HER2/HER3 heterodimer in a co-transfection experiment with HER2 and HER3. Furthermore, Arteaga et al demonstrated HER2/HER3 heterodimer formation, the association of p85 subunit of PI3K with HER3 and subsequent PI3K/Akt activation in HER2-overexpressing breast cancer cell lines (Moulder et al, 2001; Anido et al, 2003). The gene discussed is AKT1; the disease is breast cancer.