Because we detected strong vitronectin on tumour endothelium in HCC in sinusoidal-like vessels, we also tested the function of uPAR in another migration system in which fresh liver-derived lymphocytes were tested for their ability to undergo transendothelial migration across monolayers of human hepatic sinusoidal endothelium under flow. This evidence concerns the gene VTN and hepatocellular carcinoma.