Impairment of polymorphonuclear leukocyte phagocytosis and reduction in granulocyte phagocytic capacity have been reported with increased plasma glucose concentration in diabetic patients, and these abnormalities are reversed after insulin therapy.11–16 The most dramatic defect that occurs in diabetes mellitus is related to abnormalities of T cell function.17,18 The reason for these alterations in the immune cell behavior of diabetic patients is still undefined, with few studies of lymphocyte proliferation and none regarding the influence of metabolic control in diabetic patients. Here, INS is linked to diabetes mellitus.