Circulating PAI-1 levels are elevated in patients with coronary heart disease and it plays an important role in the development of atherothrombosis by decreasing fibrin degradation.17 PAI-1 is produced mainly by visceral fat tissue, chiefly the omentum and mesenteric fat.17–19 Procedures that cause reduction in PAI-1 levels have already been put forward for improving the metabolic profile and reducing the cardiovascular risk.20,21. Here, SERPINE1 is linked to coronary artery disorder.