In addition, regardless of the polymorphism, hOGG1 activity may be functionally inhibited by increased NO production resulting from chronic inflammation, which usually exists as the background of HCC, since NO mediated inhibition of hOGG1 activity has been shown in cholangiocarcinoma cell line.31 On the other hand, Sugimura et al32 reported that the risk for lung cancer associated with the hOGG1 Cys/Cys genotype differed by histological subtypes, being elevated for squamous cell carcinoma but not for adenocarcinoma. This evidence concerns the gene OGG1 and adenocarcinoma.