Since the expression of CXCR4 correlated to the magnitude of metastatic RCC cells in specific organs, we next wanted to determine whether depletion of CXCL12 by specific neutralizing antibodies to CXCL12 in SCID mice bearing SN12C-VHL-KD and SN12C-VC orthotopic tumors expressing GFP would attenuate RCC metastasis. Here, CXCR4 is linked to renal cell carcinoma.