More recently, we showed that both EGF and hypoxia can induce CXCR4 expression in non-small cell lung cancer (NSCLC) cells via the VHL/HIF-1α axis and this process is regulated by both the PI3-kinase/PTEN/AKT/mTor pathway and hypoxia [35]. This evidence concerns the gene CXCR4 and non-small cell lung carcinoma.