In the outpatient setting, the detection of silent cardiac damage (mainly left ventricular hypertrophy [LVH]) [3,4], or of renal disease (pathological urinary albumin excretion [UAE] [5,6] or diminished glomerular filtration rate [GFR] [7,8]) in patients with HT and/or DM, defines a subgroup in whom cardiovascular risk is even greater. This evidence concerns the gene ALB and left ventricular hypertrophy.