CD8A and infection: Furthermore, these three alleles, which are associated with slower disease progression in HIV-1 infection, all restrict a single highly immunodominant epitope-specific CD8+ T cell response during primary infection (TW10 for B57 [23], KK10 for B27, and TL8 for Mamu-A*01 [8,51]), suggesting that the combination of these specific epitopes in the context of the restricting major histocompatibility complex class I allele may be crucial for the described strong antiviral activity.