To date, studies of the specificity of HIV-1-specific CD8+ T cell responses during primary HIV-1 infection have been limited in size, focused on individuals expressing specific HLA alleles of interest, or assessed the protein specificity of these CD8+ T cells without determining the individual targeted epitopes in the context of the restricting HLA class I molecules [12–15,21–25]. The gene discussed is CD8A; the disease is HIV-1 infection.