For all four outcomes, the contribution of an HLA allele to the HIV-1-specific CD8+ T cell response during primary infection showed a consistent inverse correlation with the respective HR (Figure 5), and this inverse correlation trended toward significance for the outcomes AIDS 1987 (p = 0.06), AIDS 1993 (p = 0.07), and reached significance for death (p = 0.045). The gene discussed is CD8A; the disease is AIDS.