GLRX and chronic obstructive pulmonary disease: Interestingly, there was a significant correlation between Grx1 positive macrophages in the lung tissue specimens (containing lung samples from all smokers and different stages of COPD) and lung function parameters (FEV1, r = 0.45, p = 0.008; FEV1%, r = 0.46, p = 0.007, FEV/FVC%, r = 0.55, p = 0.001) as shown in figure 4 (panels A-C).