RASSF1 and retinoblastoma: Epigenetic inactivation of RASSF1A has been described in sporadic tumors such as gliomas, breast, prostate, kidney and ovarian tumors[11,12,42-44], and also in the pediatric tumors Wilms' tumor, neuroblastoma, medulloblastoma, rhabdomyosarcoma and retinoblastoma[10,45].