Epigenetic inactivation of RASSF1A has been described in sporadic tumors such as gliomas, breast, prostate, kidney and ovarian tumors[11,12,42-44], and also in the pediatric tumors Wilms' tumor, neuroblastoma, medulloblastoma, rhabdomyosarcoma and retinoblastoma[10,45]. The gene discussed is RASSF1; the disease is central nervous system cancer.