Moreover, a recent work from our labs has demonstrated that IgG AAbs elicited against the Dsg349–60REWVKFAKPCRE peptide do not have pathogenic potential, providing experimental support to contradict the possibility that the peptide administration might generate pathogenic anti-Dsg3 antibodies capable of exhacerbating pemphigus pathology. The gene discussed is DSG3; the disease is pemphigus.