Even when the arbitrary cut-off for significant expression differences was reduced to only 1.5 fold, the statistically significant association between up-regulation of SnoN in MSS CRCs and down-regulation in MSI-H CRCs was maintained (P ≤ 0.001), suggesting that even subtle changes in SnoN gene expression levels are capable of exerting a functional effect. This evidence concerns the gene SKIL and Marinesco-Sjogren syndrome.