SKIL and colorectal neoplasm: Interestingly, increased copy number of Ski was found to be a negative prognostic indicator whilst no correlation with patient outcome was observed for SnoN. Since regulation of TGFβ signalling by SnoN involves a combination of proteolytic degradation and transcriptional up-regulation in addition to changes in copy number, we suggest that quantification of SnoN expression may be a more informative way to assess its role in colorectal tumour development.