Our data combined with that of others (Ito et al, 2002; Diaz et al, 2006; Madan et al, 2006; Planas-Silva et al, 2006), suggests that compared to normal breast epithelium, increased levels of activated c-Src are present in DCIS and invasive breast carcinoma. The gene discussed is SRC; the disease is ductal breast carcinoma in situ.