Although numerous studies have demonstrated elevated c-Src activity in breast carcinoma (Jacobs and Rubsamen, 1983; Ottenhoff-Kalff et al, 1992; Verbeek et al, 1996), there have been discrepancies between tumour histological grade and activated c-Src (Ito et al, 2002). The gene discussed is SRC; the disease is breast carcinoma.