PTGS1 and schizophrenia: As cyclooxygenase-1 and cyclooxygenase-2 are both constitutively expressed in the brain [16], both the older COX-1 NSAIDS such as acetylsalicylic acid and indomethacin and the newer selective COX-2 NSAIDS such as celecoxib may theoretically impede the pathologic process in schizophrenia.