HMGCR and astrocytoma (excluding glioblastoma): In order to study whether the antipsychotic-induced SREBP activation is valid in more than one CNS-related human cell line, we examined HMGCR expression in astrocytoma CCF-STTG1 cells, neuroblastoma SH-5YSY cells, and cortical neuronal HCN2 cells, all exposed to clozapine or haloperidol for 24 hours.