In contrast, the SH-SY5Y neuroblastoma cells displayed minimal activation of the SREBP transcription system upon drug exposure, with a relative increase in HMGCR expression of 1.5 ± 0.1 and 1.4 ± 0.1 by haloperidol (25 μM) and clozapine (25 μM), respectively (Table 2). This evidence concerns the gene HMGCR and neuroblastoma.