While some tumors have intrinsically poor immunogenicity and avoid immune response even when CTLA-4 is blocked, combining CTLA-4 blockade with vaccination against tumor-specific proteins and/or with therapies that lead to increased death of tumor cells (which also boost presentation of tumor proteins by antigen-presenting cells) can substantially improve the recognition and elimination of such tumors. This evidence concerns the gene CTLA4 and neoplasm.