In light of the neurogenesis-enhancing effects of G-CSF it is highly interesting that, at least for ischemia-induced neurogenesis, there is no clear time dependence from the insult, and increased neurogenesis may keep up for months after stroke [18], thereby likely providing a long period of susceptibility to therapeutic interference by neurogenesis-enhancing substances such as G-CSF. This evidence concerns the gene CSF3 and Stroke.