Several reports revealed positive correlations between nuclear localization of ErbB receptors and expression of target genes and nuclear partners in cancer cells: for example, ErbB2/HER2 and COX2 in choloangiocarcinoma, colon cancer and breast cancer [47]; also EGFR and cyclin D1/iNOS/STAT3 in breast cancers ([48], reviewed in [109]). The gene discussed is CCND1; the disease is breast cancer.