Looking at the functional significance of BRCA1 hypermethylation, we found that methylation (n=32 AML samples) correlated to reduced BRCA1 expression, when compared to unmethylated samples (n=24, mean relative amount of BRCA1: 2.2±0.7 vs 9.2±3.4, P=0.019, Figure 4A). This evidence concerns the gene BRCA1 and acute myeloid leukemia.