BRCA1 and acute myeloid leukemia: Median expression of DNMT3A was higher in AML samples with hypermethylated BRCA1 in comparison to unmethylated samples (Figure 4B, P=0.003), whereas expression levels of DNMT1 and 3B did not differ according to BRCA1 methylation (P=0.22 and 0.07, respectively).