The number of samples analysed is small, but three of four breast cancers showed BRCA1 hypermethylation, which might indicate that in breast cancer complicated by a t-AML, the frequency of BRCA1 hypermethylation is higher than the 11–31% reported in the literature (Catteau and Morris, 2002). The gene discussed is BRCA1; the disease is acute myeloid leukemia.