The downregulation of the key adipogenic factors (C/EBPβ, C/EBPα, PPARγ and SREBP-1c) together with the repression of lipogenic factors (ACC, FAS, SCD-1, GPAT and Glut-4) suggests that impairment in the formation and lipid storing capacity of adipose tissue occurs in cancer cachexia. The gene discussed is SCD; the disease is cancer.