EGFR and non-small cell lung carcinoma: As two separate groups reported somatic mutations of the EGFR TK domain in NSCLC in May 2004 (Lynch et al, 2004; Paez et al, 2004), over 15 studies on mutational analysis of this domain (exons 18–21) in over 3000 patients have been reported by different groups around the world (Chan et al, 2006).