Specifically, NPI-0052-induced MM cell death correlates with (1) decrease in ΔΨm; (2) increase in O2− production; (3) the release of cytochrome c and smac from mitochondria to cytosol; and (4) activation of caspase-9, caspase-8, and caspase-3, followed by PARP cleavage. The gene discussed is CASP8; the disease is Miyoshi myopathy.