Considering the possible effect of VEGF-C/sVEGFR-3 on lymphatic dilation and lymphedema development, a combination of classical antifilarial plus antiwolbachial therapy, which will reduce production of proinflammatory cytokines, may prove to be more effective in treating pathogenesis associated with LF than antifilarial therapy alone. This evidence concerns the gene VEGFC and lymphedema.