What can be concluded from the available data are the following: (1) serum levels of VEGF-C are usually 10-fold higher than plasma levels, because of release from platelets during coagulation; this also means that plasma levels would be the more reliable marker since there is no (dominant) interference by platelet-derived VEGF-C [64]; and (2) measurement of plasma VEGF-C levels in cancer patients revealed 3-fold higher levels in comparison to controls [65]. This evidence concerns the gene VEGFC and cancer.