Indeed, IGF-IR inhibition, using either dominant negative or pharmacological approaches, has been shown to inhibit breast tumour growth and metastasis both in vitro and in vivo (Arteaga et al, 1989; Arteaga and Osborne, 1989; Burtrum et al, 2003; Sachdev et al, 2003; Sachdev et al, 2004). Here, IGF1R is linked to breast neoplasm.