DIO1 and neurodegenerative disease: Selenium forms the integral part of the enzyme glutathione peroxidase, type I iodothyronine deiodinase, metalloprotein, fatty acid binding protein and selenoprotein P. therefore selenium is considered as an antioxidant nutrient and the diseases where low selenium is implicated range from nutritional disorders like protein energy malnutrition to degenerative diseases such as cancer [40].