A mathematical model describing the production and clearance of HIV-1 and latently infected cells during ART isAs in previous mathematical models, which describe various aspects of HIV-1 dynamics [1,6,31,32], this model includes T representing CD4+ T cells that are susceptible to infection (target cells), T* productively infected cells, L latently infected cells, M long-lived CD4+ cells, M* productively infected long-lived cells, VI infectious virus, and VNI noninfectious virus-produced by the action of protease inhibitors (PIs), respectively. This evidence concerns the gene CD4 and infection.