Also in the nonsupplementing families, CBS was associated by PDT with the broad phenotype in rs234715 (p = 0.015) and rs4920037 (p = 0.037) and SNPs in MTR showed significance: rs1092535 (narrow PDT p = 0.066, narrow APL p = 0.031, broad PDT p = 0.040, broad APL p = 0.04) and rs4659743 (narrow APL p = 0.013, broad PDT p = 0.041, broad APL p = 0.010). The gene discussed is CBS; the disease is acute promyelocytic leukemia.