PTGS2 and oligodendroglial tumor: Upregulation of angiogenesis factors and a variety of genetic alterations including deletion of CDKN2A, loss of chromosome 10, downregulation of ATase and cyclooxygenase-2 expression have been associated with progression and poor prognosis in oligodendroglial neoplasms (Jaeckle et al, 1998; Castilla et al, 2003; Hartmann et al, 2004; Jeuken et al, 2004).