However, a number of studies have shown that biallelic mutations in MYH account for only a minority of sporadic colorectal cancers (Enholm et al, 2003; Croitoru et al, 2004; Fleischmann et al, 2004; Wang et al, 2004; Farrington et al, 2005; Peterlongo et al, 2005). Here, MUTYH is linked to colorectal cancer.