FSCN1 and neoplasm: Cox multivariant analysis demonstrated that lymph node metastasis (N1, 2) was an independent adverse prognostic factor; however, fascin (high), age (>65 years), gender (male) and tumor location (proximal) were not independent prognostic factors in the total group of 131 patients with stage I-IV colorectal adenocarcinoma (Table 4).