KIT and neoplasm: The designation of these tumours has largely been based on the immunohistochemical expression of c-KIT (CD 117; stem cell factor [6,7], and CD 34) [8], with a relative lack of desmin and S-100 immunoreactivity, although recently, a subset of KIT-negative GISTs has been recognised with the morphological features of classical stromal tumours but retaining PKC-theta expression [9].