Both physiological and pathological stimuli such as hypoxia induce tumour cells, together with leukocytes, macrophages, mast cells and platelets, to secrete VEGF and other growth-related factors such as platelet-derived growth factor (PDGF) family proteins and their receptors (PDGFR), insulin-like growth factor (IGF) proteins and their receptors (IGFR), circulating endothelial precursor cell (CEPC), fibroblast growth factors (FGF)-2, angiopoietins, EphrinB2 and EphB4 [13]. The gene discussed is VEGFA; the disease is neoplasm.