The PINCH protein is detected not only in fibroblasts, but also in myofibroblasts and in a proportion of endothelial cells of the tumour vasculature (whereas normal epithelial and tumour cells do not show any staining) supporting the involvement of PINCH in promoting tumour-stromal interactions that support tumour progression [179,212]. The gene discussed is LIMS1; the disease is neoplasm.