Recent studies showing that another polycomb protein, EZH2, which is essential for BMI-1 recruitment to the polycomb body in the nucleus (Hernandez-Munoz et al, 2005), is also highly expressed in many cancers and led us to extend our studies to include both BMI-1 and EZH2. As expression of these two proteins is often mutually exclusive, a sensible approach may be an attempt to target both. The gene discussed is EZH2; the disease is cancer.