ADAM8 and osteosarcoma: By comparing the highly metastatic K7M2 and K12 murine osteosarcoma cell lines using cDNA microarray technology, Khanna et al. [13] identified 10 potential genes involved in the metastatic process in osteosarcoma: ITGB4 (integrin β4), CTGF (connective tissue growth factor), ITGA5 (integrin α5), VIL2 (ezrin), ITGB2 (integrin β2), LGALS3 (galectin-3), ADAM8 (a disintegrin and metalloprotease domain 8), CLU (clusterin), FARP1 (FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1) and CP (ceruloplasmin).