Sequencing of KEAP1 in 40 primary lung tumors and 16 PF samples from lung cancer patients revealed deletion, insertion, missense, and frameshift mutations in KEAP1 in a total of ten tumors, and the frequency of mutations in PTs and PF was 15% (6/40) and 25% (4/16), respectively. This evidence concerns the gene KEAP1 and lung cancer.