Individually, each of these polymorphisms only moderately predisposes to type 2 diabetes with odds ratios (ORs) ranging from ~1.15 for the Lys23 variant of the KCNJ11 variant to ~1.50 for the rs7903146 variant of TCF7L2. Throughout this paper we use Pro12, Lys23, and “T at rs7903146” to refer to the risk alleles in the genes PPARG, KCNJ11, and TCF7L2, respectively. This evidence concerns the gene PPARG and type 2 diabetes mellitus.