Subsequently, two further heterozygous mutations in the ligand binding domain (LBD) of PPARγ (R425C; F388L) have been described, with recognition that in addition to insulin resistance the phenotype also includes a stereotyped pattern of partial lipodystrophy (PLD) (Hegele et al., 2002; Agarwal and Garg, 2002; Savage et al., 2003). This evidence concerns the gene PPARG and Insulin resistance.