ESR1 and neoplasm: In a multivariate model that included tumor grade, stage and the ER, PR, and Her-2 status, as well as levels of VEGF, IL-8, MVD, and eIF4E found in the tissues; eIF4E emerged as an independent prognostic factor for OS (p = 0.001), along with stage (P = 0.005), node status (P = 0.046), and the MVD present (P = 0.004).