Given these results and the established oncogenic/transforming potentials of Tiam1 and its downstream target Rac in other cell types, one might speculate that a cross-talk between Wnt/β-catenin and Tiam1-Rac signaling plays a major role in the development of prostate cancer, although the underlying molecular mechanism remains to be determined. The gene discussed is AKT1; the disease is prostate carcinoma.