Earlier studies utilising immunohistochemistry have shown that the overexpression of p53 and p16 and reduced expression of cyclin D1 were associated with HPV-positive tumours but 11q13 amp was not evaluated and these studies only included tumours arising in the tonsils (Andl et al, 1998; Li et al, 2004). The gene discussed is TP53; the disease is neoplasm.