Weinberger et al (2006) has shown that patients with HPV-positive tumours which express high levels of p16 protein and low levels of p53 protein present with a favourable prognosis. We have shown in our study that HPV-positive tumours have high levels of p16 expression and wild-type TP53 and in addition, a low frequency of amplification at 11q13. The gene discussed is TP53; the disease is neoplasm.